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America's Best Cities For Global Trade 2015

Irvine, CA

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Written by Haylle Sok

IRVINE, California
Population: 236,716
Unemployment: 4.3 percent
Leading Industries: Education, Medical

This is a highly educated, highly skilled workforce that gets paid as such; median household income is above $90,000. Large international tech and science-related companies such as Allergan and Broadcom are headquartered in Irvine, which has the lowest crime rate for a city of more than 100,000 and one of the best school systems in the country. University of California, Irvine, with an emphasis in medicine, tech and business, was recently ranked No. 1 on a list of U.S. universities under 50 years old.